Download or read book Dry Granulation Process and Compaction Behavior of Granulated Powders written by Lucia Perez-Gandarillas and published by . This book was released on 2016 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Particulate solids such as pharmaceutical powders often require size enlargement processes to improve the manufacturing properties like flowability. For that reason, dry granulation by roll compaction has been widely used in the pharmaceutical industry. The process consists of compressing powders between two counter-rotating rolls to produce ribbons that will be subsequently milled into granules. The obtained granules are tableted for oral dosage. In this process there are two main limitations: the existence of different designs of the roll compactors, milling systems and the interaction between process parameters and raw material properties are still a challenge and the roll-compaction process leads to an inferior tensile strength of tablets compared with direct compression. These aspects are investigated in this work. In the first part of this thesis, an analysis on the effect of different roll-compaction conditions and milling process parameters on ribbons, granules and tablet properties was performed, highlighting the role of the sealing system and the ribbon density distribution characteristics. In the second part, die compaction of roll-compacted powders, as the last stage of the process, is further investigated in terms of experimental analysis (effect of the granule size and composition and stress transmission measurements) and modelling the compaction behavior of granules.