Download or read book Physics-based Vaccine Design written by Daniel William Biner and published by . This book was released on 2020 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational epitope discovery has traditionally been complicated by multiple scales of epitope organization and a lack of structurally characterized epitopes. To provide a theoretical account of clinically relevant epitope physics, all-atom Molecular Dynamics simulations were run on the Zika virus structure. Four epitope discovery algorithms were developed against six preexisting algorithms and thirty-eight flavivirus-antibody structures. For the first time, virus protein flexibility was shown to outperform solvent accessible surface area at epitope discovery! A new epitope discovery benchmarking method was introduced, highlighting bias in previous epitope analyses. New methods for 1) quantifying virus-like particle flexibility and 2) predicting vaccine self-assembly facilitating peptides were also presented.