Download or read book Thermo-mechanical Behavior of Pharmaceutical Powders During Compaction Processes written by Sagar Laxmiprasad Uniyal and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dry granulation / roller compaction is an enlargement process by agglomeration of the primary powders without adding any solvent. This operation makes it possible to homogenize the properties of pharmaceutical formulations and improve the flow properties necessary for the manufacture of tablets using rotary presses. In this process, temperature variations in the product are rarely considered. However, recent studies have shown that for pharmaceutical powders, such variations can lead to changes in mechanical and physico-chemical properties. In this thesis, a new method based on in-line measurements of powders temperature compacted by a roller press is developed using an infrared camera. Temperature distributions on the surface of the compact were determined using infrared radiation emitted by the compact after leaving the gap. These distributions showed a correlation with the microstructural properties of the compact, confirming the potential of this procedure in monitoring product quality. To understand the potential sources of the heating of pharmaceutical products in dry granulation, a heat balance model was established in anticipation of the numerical simulation of the thermomechanical coupling of the process by finite element method. As the thermal properties of the compact depend on the relative density, the thermal conductivity and the specific heat were characterized for two model pharmaceutical excipients. In addition, the impact of dry granulation on the rearrangement and densification of granules in die compression is studied using a mathematical model (Cooper-Eaton) which allowed to a better understanding of the contribution of dry granulation to tableting process.