Download or read book Endothelin Receptors and Signaling Mechanisms written by David M. Pollock and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.